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Maintenance of an Unusual Polypurine Tract in Hiv-2 - Stability to Passage in Culture

  1. Author:
    Lauermann, V.
    Hughes, S. H.
    Peden, K. W. C.

  2. Author Address

    Peden KWC US FDA CTR BIOL EVALUAT & RES LAB RETROVIRUS RES 29 LINCOLN DR BLDG 29A ROOM 3D08 BETHESDA, MD 20892 USA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM FREDERICK, MD 21702 USA US FDA CTR BIOL EVALUAT & RES LAB RETROVIRUS RES BETHESDA, MD 20892 USA
    1. Year: 1997
  2. Journal: Virology
    1. 236
    2. 1
    3. Pages: 208-212
  4. Type of Article: Article
  1. Abstract:

    A stretch of purine residues, the polypurine tract (PPT), is found in all retroviruses and is used to initiate plus-strand DNA synthesis. While the PPT of most lentiviruses is a homogeneous sequence of purine residues, the PPT of some isolates of the human and simian immunodeficiency viruses is interrupted with a single pyrimidine residue. The ROD strain of human immunodeficiency virus type 2 (HIV-2) has such a pyrimidine-containing variant PPT. Virus generated from an infectious molecular clone, pROD10, was used to infect two CD4-positive T-cell lines, H9 and CEM. The sequence of the PPT was determined after two passages. From both cell lines, the variant PPT was retained, demonstrating that the presence of a pyrimidine in the PPT was fully functional and that there was no strong selection for an all-purine PPT. (C) 1997 Academic Press. [References: 41]

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