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L-selectin (CD62L) expression distinguishes small resting memory CD4(+) T cells that preferentially respond to recall antigen

  1. Author:
    Hengel, R. L.
    Thaker, V.
    Pavlick, M. V.
    Metcalf, J. A.
    Dennis, G.
    Yang, J.
    Lempicki, R. A.
    Sereti, I.
    Lane, H. C.

  2. Author Address

    NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, 11B05,Bldg 10,9800 Rockville Pike, Bethesda, MD 20892 USA NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, Bethesda, MD 20892 USA Georgetown Univ, Sch Med, Dept Med, Div Infect Dis, Washington, DC 20053 USA NIAID, Off Clin Director, NIH, Bethesda, MD 20892 USA Sci Applicat Int Corp, Lab Immunopathogenesis & Bioinformat, Frederick, MD 21702 USA Hengel RL NIAID, Clin & Mol Retrovirol Sect, Immunoregulat Lab, NIH, 11B05,Bldg 10,9800 Rockville Pike, Bethesda, MD 20892 USA
    1. Year: 2003
  2. Journal: Journal of Immunology
    1. 170
    2. 1
    3. Pages: 28-32
  4. Type of Article: Article
  1. Abstract:

    Naive CD4(+) T cells use L-selectin (CD62L) expression to facilitate immune surveillance. However, the reasons for its expression on a subset of memory CD4(+) T cells are unknown. We show that memory CD4(+) T cells expressing CD62L were smaller, proliferated well in response to tetanus toxoid, bad longer telomeres, and expressed genes and proteins consistent with immune surveillance function. Conversely, memory CD4(+) T cells lacking CD62L expression were larger, proliferated poorly in response to tetanus toxoid had shorter telomeres, and expressed genes and proteins consistent with effector function. These findings suggest that CD62L expression facilitates immune surveillance by programming CD4(+) T cell blood and lymph node recirculation, irrespective of naive or memory CD4(+) T cell phenotype.

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