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Common sites of retroviral integration in mouse hematopoietic tumors identified by high-throughput, single nucleotide polymorphism-based mapping and bacterial artificial chromosome hybridization

  1. Author:
    Shen, H. F.
    Suzuki, T.
    Munroe, D. J.
    Stewart, C.
    Rasmussen, L.
    Gilbert, D. J.
    Jenkins, N. A.
    Copeland, N. G.

  2. Author Address

    Natl Canc Inst Frederick, Mouse Canc Genet Program, Ft Detrick, MD 21702 USA Natl Canc Inst Frederick, Mouse Canc Genet Program, Ft Detrick, MD 21702 USA SAIC Frederick, Lab Mol Technol, Ft Detrick, MD 21702 USA Copeland NG Natl Canc Inst Frederick, Mouse Canc Genet Program, Ft Detrick, MD 21702 USA
    1. Year: 2003
  2. Journal: Journal of Virology
    1. 77
    2. 2
    3. Pages: 1584-1588
  4. Type of Article: Article
  1. Abstract:

    Retroviral insertional mutagenesis in mouse hematopoietic tumors provides a powerful cancer gene discovery tool. Here, we describe a high-throughput, single nucleotide polymorphism (SNP)-based method, for mapping retroviral integration sites cloned from mouse tumors, and a bacterial artificial chromosome (BAC) hybridization method, for localizing these retroviral integration sites to common sites of retroviral integration (CISs). Several new CISs were identified, including one CIS that mapped near Notch1, a gene that has been causally associated with human T-cell tumors. This mapping method is applicable to many different species, including ones where few genetic markers and little genomic sequence information are available. It can also be used to map endogenous proviruses.

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