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Novel Kaposi's sarcoma-associated herpesvirus homolog in baboons

  1. Author:
    Whitby, D.
    Stossel, A.
    Gamache, C.
    Papin, J.
    Bosch, M.
    Smith, A.
    Kedes, D. H.
    White, G.
    Kennedy, R.
    Dittmer, D. P.

  2. Author Address

    Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, 940 Stanton L Young Blvd, Oklahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, Oklahoma City, OK 73104 USA Univ Oklahoma, Hlth Sci Ctr, Dept Lab Anim Sci, Oklahoma City, OK 73104 USA NCI, SAIC Frederick, AIDS Vaccine Program, Viral Epidemiol Sect, Frederick, MD 21702 USA NW Hosp, Seattle, WA USA Univ Virginia, Dept Microbiol, Charlottesville, VA 22908 USA Univ Virginia, Dept Internal Med, Charlottesville, VA 22908 USA Texas Tech, Dept Microbiol & Immunol, Lubbock, TX USA Dittmer DP Univ Oklahoma, Hlth Sci Ctr, Dept Microbiol & Immunol, 940 Stanton L Young Blvd, Oklahoma City, OK 73104 USA
    1. Year: 2003
  2. Journal: Journal of Virology
    1. 77
    2. 14
    3. Pages: 8159-8165
  4. Type of Article: Article
  1. Abstract:

    Kaposi's sarcoma (KS) and lymphoproliferative diseases induced by KS-associated herpesvirus (KSHV/ human herpesvirus 8) cause substantial morbidity and mortality in human immunodeficiency virus-infected individuals. To understand KSHV biology it is useful to investigate closely related rhadinoviruses naturally occurring in nonhuman primates. Here we report evidence for a novel KSHV homolog in captive baboon species (Papio anubis and other). Using degenerate PCR we identified a novel rhadinovirus, PapRV2, that has substantial sequence identity to two essential KSHV genes, the viral polymerase and thymidylate synthase. A subset of animals exhibited detectable PapRV2 viral load in peripheral blood mononuclear cells. Extensive serological analysis of nearly 200 animals in the colony demonstrated that the majority carried cross-reacting antibodies that recognize KSHV or macaque rhadinovirus antigens. Seroreactivity increased with age, similar to the age-specific prevalence of KSHV in the human population. This establishes baboons as a novel resource to investigate rhadinovirus biology, which can be developed into an animal model system for KSHV-associated human diseases, vaccine development, and therapy evaluation.

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