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A cohort study of health effects of human T-cell lymphotropic virus type I infection in Jamaican children

  1. Author:
    Maloney, E. M.
    Wiktor, S. Z.
    Palmer, P.
    Cranston, B.
    Pate, E. J.
    Cohn, S.
    Kim, N.
    Miley, W.
    Thomas, T. L.
    Blattner, W. A.
    Hanchard, B.

  2. Author Address

    NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS-8006,MSC 7248, Rockville, MD 20852 USA NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Bethesda, MD 20892 USA NCI, Radiat Epidemiol Branch, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Bethesda, MD 20892 USA Univ W Indies, Dept Pathol, Kingston 7, Jamaica Res Triangle Inst, Rockville, MD USA Sci Applicat Int Inc, Frederick, MD USA Uniformed Serv Univ Hlth Sci, Dept Prevent Med & Biometr, Bethesda, MD 20814 USA Maloney EM NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS-8006,MSC 7248, Rockville, MD 20852 USA
    1. Year: 2003
  2. Journal: Pediatrics
    1. 112
    2. 2
    3. Pages: E116-E122
  4. Type of Article: Article
  1. Abstract:

    Objective. Human T-cell lymphotropic virus type I (HTLV-I) infection in childhood is believed to play an important role in risk for adult T-cell leukemia/lymphoma. Although HTLV-I is known to be associated with infective dermatitis in childhood, other HTLV-I-associated morbidity in children has not been well studied. We sought to determine the HTLV-I-associated health effects in Jamaican children. Methods. We compared incidence rates of several health outcomes in 28 HTLV-I-infected and 280 uninfected children clinically followed from age 6 weeks to a maximum of 10 years. Cox proportional hazards regression analysis was used to analyze these prospectively collected data, adjusting for confounding effects of other variables as necessary. Results. HTLV-I-infected children had significantly higher incidence rates of seborrheic dermatitis ( rate ratio [RR]=4.8, 95% confidence interval [CI]=1.9 - 12.5), eczema (RR=3.1, CI=1.2-7.9) and persistent hyperreflexia (RR=3.7, CI=1.6-8.2). Additionally, HTLV-I infected children had increased rates of severe anemia (RR=2.5, CI=0.8-7.9) and abnormal lymphocytes (RR=2.4, CI=0.8-7.6) that were of borderline statistical significance. Conclusions. Our study suggests that HTLV-I-associated skin diseases of childhood may include seborrheic dermatitis and eczema. Additionally, these data suggest that persistent hyperreflexia of the lower limbs may be an early sign of HTLV-I-associated neurologic involvement in children. Expansion and continued clinical observation of this cohort would be valuable.

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