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Promising molecular targets for cancer prevention: AP-1, NF- kappa B and Pdcd4

  1. Author:
    Young, M. R.
    Yang, H. S.
    Colburn, N. H.

  2. Author Address

    NCI, Gene Regulat Sect, Basic Res Lab, Frederick, MD 21702 USA NCI, Gene Regulat Sect, Basic Res Lab, Frederick, MD 21702 USA Young MR NCI, Gene Regulat Sect, Basic Res Lab, Frederick, MD 21702 USA
    1. Year: 2003
  2. Journal: Trends in Molecular Medicine
    1. 9
    2. 1
    3. Pages: 36-41
  4. Type of Article: Review
  1. Abstract:

    There are still many unanswered questions regarding the processes by which extracellular signals are transduced from plasma-membrane receptors to the transcription machinery in the nucleus and the translation machinery in the cytoplasm. Some of these gene expression events become misregulated as a result of environmental or endogenous exposure to agents that cause multistage carcinogenesis. We are now beginning to identify and validate the crucial molecular events that drive the rate- limiting steps of carcinogenesis and to target these events for cancer prevention. Transcription factors AP-1 and nuclear factor kappaB can be specifically targeted to prevent cancer induction in mouse models. A protein known as program med-cell- death-4 is a new potential molecular target that has a surprising mode of action.

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