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Interplay between plasmid partition and postsegregational killing systems

  1. Author:
    Brendler, T.
    Reaves, L.
    Austin, S.

  2. Author Address

    Austin, S, GRCBL, NCI Frederick, NCI, PO Box B, Ft Detrick, MD 21702 USA GRCBL, NCI Frederick, NCI, Ft Detrick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Journal of Bacteriology
    1. 186
    2. 8
    3. Pages: 2504-2507
  4. Type of Article: Article
  1. Abstract:

    Active partition systems and postsegregational killing (PSK) systems are present together in naturally occurring low-copy-number plasmids. Theory suggests that PSK may act as the ultimate determinant of plasmid retention, whereas the partition system may minimize the growth penalty to the host, resulting in a near-ideal symbiosis when the systems combine. Here, we prove the validity of this principle for a specific case involving the P1par system and the mvp PSK system

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