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Characterization of a new SNP c767A/T (Arg222Trp) in the candidate TSG FUS2 on human chromosome 3p21.3: prevalence in Asian populations and analysis of association with nasopharyngeal cancer

  1. Author:
    Duh, F. M.
    Fivash, M.
    Moody, M.
    Lung, M. L.
    Guo, X.
    Stanbridge, E.
    Dean, M.
    Voevoda, M.
    Hu, L. F.
    Kashuba, V.
    Zabarovsky, E. R.
    Qian, C. N.
    Godbole, S.
    Teh, B. T.
    Lerman, M. I.

  2. Author Address

    Duh, FM, NCI, SAIC Frederick Inc, Basic Res Program, Ft Detrick, MD 21702 USA NCI, SAIC Frederick Inc, Basic Res Program, Ft Detrick, MD 21702 USA. NCI, Frederick Canc Res & Dev Ctr, Data Management Serv Inc, Ft Detrick, MD 21702 USA. NCI, Canc Res Ctr, Immunobiol Lab, Ft Detrick, MD 21702 USA. Hong Kong Univ Sci & Technol, Dept Biol, Hong Kong, Hong Kong, Peoples R China. Natl Sun Yat Sen Univ, Ctr Canc, Guangzhou 510060, Peoples R China. Univ Calif Irvine, Dept Microbiol & Mol Genet, Irvine, CA 92695 USA. NCI, Canc Res Ctr, Lab Genom Divers, Frederick, MD 21702 USA. Russian Acad Sci, Inst Cytol & Genet, Siberian Branch, Novosibirsk 630090, Russia. Russian Acad Med Sci, Inst Internal Med, Siberian Branch, Novosibirsk 630090, Russia. Karolinska Inst, Ctr Microbiol & Tumor Biol, Ctr Genom & Bioinformat, S-17177 Stockholm, Sweden. Queen Elizabeth Hosp, Dept Ear Nose & Throat, Sabah 88586, Malaysia. Van Andel Res Inst, Canc Genet Lab, Grand Rapids, MI 49503 USA.
    1. Year: 2004
  2. Journal: Molecular and Cellular Probes
    1. 18
    2. 1
    3. Pages: 39-44
  4. Type of Article: Article
  1. Abstract:

    The FUS2 gene, encoding a novel cytoplasmic acetyltransferase, resides in the tumor suppressor gene region on human chromosome 3p21.3 and is considered a promising candidate tumor suppressor gene. We have identified a new single nucleotide polymorphism (SNP), c767A/T, in the coding region of the gene. The polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase (GNAT) and the proline-rich domains of the protein. We have analyzed 254 subjects included in 14 sub-populations. The occurrence of the SNP varies with the ethnicity of the population, suggesting that this SNP could be a valuable biomarker for population genetics. It is most prevalent in various Asian populations (T allele frequency > 0.54), followed by the Canadian polar Inuit (T allele frequency = 0.3), African American (T allele frequency = 0.17), and Caucasian population (T allele frequency = 0.1). Since nasopharyngeal carcinoma (NPC) is frequent in Southern China, Taiwan, Borneo and polar Canada, we further tested for the possible association of the FUS2 SNP with this form of endemic cancer. Our analysis, albeit limited, suggests no likely association between NPC and the FUS2 gene polymorphism. Further large-scale case-control studies are necessary and warranted to prove the strength of this contention. (C) 2003 Elsevier Ltd. All rights reserved

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