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Association of strong virus-specific CD4 T cell responses with efficient natural control of primary HIV-1 infection

  1. Author:
    Gloster, S. E.
    Newton, P.
    Cornforth, D.
    Lifson, J. D.
    Williams, I.
    Shaw, G. M.
    Borrow, P.

  2. Author Address

    Borrow, P, Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England Edward Jenner Inst Vaccine Res, Newbury RG20 7NN, Berks, England. Royal Free & Univ Coll, Sch Med, Ctr Sexual Hlth & HIV Res, London, England. Camden Primary Care Trust, London, England. Natl Canc Inst, AIDS Vaccine Program, SAIC Frederick Inc, Frederick, MD USA. Univ Alabama, Howard Hughes Med Inst, Div Hematol Oncol, Dept Med, Birmingham, AL 35294 USA.
    1. Year: 2004
  2. Journal: Aids
    1. 18
    2. 5
    3. Pages: 749-755
  4. Type of Article: Article
  1. Abstract:

    Objective: To investigate whether there are differences in the virus-specific CD4 T cell response during primary HIV-1 infection in patients who naturally (without antiretroviral intervention) control viral replication with differing efficiencies.Methods: CD4 T cell responses to recombinant HIV proteins (Gag p24 and p55 and Env gp160) and an inactivated HIV-1 preparation were analysed using interferon-gamma ELISPOT assays (with CD8-depleted peripheral blood mononuclear cells) and by intracellular interferon-gamma staining and fluorescent-activated cell sorting.Results: Strong HIV-specific CD4 T cell responses were detected from the earliest time-points analysed in primary infection in patients who naturally established low persisting viral loads. By contrast, HIV-specific CD4 T cell responses were weaker (at or just below the limit of detection in our assays) at similar time-points in patients who went on to establish high persisting viral loads. Statistical analysis revealed a highly significant difference (P < 0.001) between the magnitudes of the Gag p24-specific response at the earliest time-point analysed in primary infection in the two sets of patients.Conclusions: Strong HIV-specific CD4 T cell responses are associated with efficient natural control of primary HIV-1 infection. (C) 2004 Lippincott Williams Wilkins

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