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HTLV-1-encoded p30(II) is a post-transcriptional negative regulator of viral replication

  1. Author:
    Nicot, C.
    Dundr, M.
    Johnson, J. M.
    Fullen, J. R.
    Alonzo, N.
    Fukumoto, R.
    Princler, G. L.
    Derse, D.
    Misteli, T.
    Franchini, G.

  2. Author Address

    Franchini, G, NCI, Anim Models & Retroviral Vaccines Sect, 41-D804, Bethesda, MD 20892 USA NCI, Anim Models & Retroviral Vaccines Sect, Bethesda, MD 20892 USA. NCI, Lab Receptor Biol & Gene Express, Bethesda, MD 20892 USA. NCI, Basic Res Lab, Ctr Canc Res, Ft Detrick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Nature Medicine
    1. 10
    2. 2
    3. Pages: 197-201
  4. Type of Article: Article
  1. Abstract:

    Human T-cell leukemia/lymphoma virus type 1 (HTLV-1) persists despite a vigorous virus-specific host immune response, and causes adult T-cell leukemia and lymphoma in approximately 2% of infected individuals. Here we report that HTLV-1 has evolved a genetic function to restrict its own replication by a novel post-transcriptional mechanism. The HTLV-1-encoded p30(II) is a nuclear-resident protein that binds to, and retains in the nucleus, the doubly spliced mRNA encoding the Tax and Rex proteins. Because Tex and Rex are positive regulators of viral gene expression(1,2), their inhibition by p30(II) reduces virion production. p30(II) inhibits virus expression by reducing Tax and Rex protein expression

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