Skip NavigationSkip to Content
Return Return to Search Results

To knockout in 129 or in C57BL/6: that is the question

  1. Author:
    Seong, E.
    Saunders, T. L.
    Stewart, C. L.
    Burmeister, M.

  2. Author Address

    Burmeister, M, Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA Univ Michigan, Mental Hlth Res Inst, Ann Arbor, MI 48109 USA. Univ Michigan, Neurosci Program, Ann Arbor, MI 48109 USA. Univ Michigan, Dept Internal Med, Ann Arbor, MI 48109 USA. NCI, Canc & Dev Biol Lab, Frederick, MD 21701 USA. Univ Michigan, Dept Psychiat, Ann Arbor, MI 48109 USA. Univ Michigan, Dept Human Genet, Ann Arbor, MI 48109 USA.
    1. Year: 2004
  2. Journal: Trends in Genetics
    1. 20
    2. 2
    3. Pages: 59-62
  4. Type of Article: Article
  1. Abstract:

    Traditionally, knockout experiments are performed in ES cells derived from the 129 mouse strain, followed by backcrossing with the more robust C57BL/6 strain. C57BL/6-derived ES cells have only occasionally been used in this process. We compared C57BL/6- with 129-derived ES cells directly and reviewed the literature. We found that, although some steps are less efficient, the advantages of C57BL/6 mice more than compensate for these drawbacks

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel