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Raji B cells, misidentified as THP-1 cells, stimulate DC-SIGN-mediated HIV transmission

  1. Author:
    Wu, L.
    Martin, T. D.
    Carrington, M.
    KewalRamani, V. N.

  2. Author Address

    KewalRamani, VN, NCI, Model Dev Sect, HIV Drug Resistance Program, NIH, Frederick, MD 21702 USA NCI, Model Dev Sect, HIV Drug Resistance Program, NIH, Frederick, MD 21702 USA. NCI, Basic Res Program, SAIC Frederick Inc, NIH, Frederick, MD 21702 USA.
    1. Year: 2004
  2. Journal: Virology
    1. 318
    2. 1
    3. Pages: 17-23
  4. Type of Article: Article
  1. Abstract:

    A number of studies examining interactions of dendritic cell (DC)-specific ICAM-3 grabbing nonintegrin (DC-SIGN) with viral pathogens have relied on monocytic transfectants as models for primary DCs. Here we show that the presumed "THP-1" monocytic cells used in these studies are instead Raji B cells. Moreover, we demonstrate that true THP-1 cells do not support DC-SIGN-mediated HIV-1 transmission, whereas human B cell lines efficiently enhance this process. These data indicate that there are features common to B cells and DCs that facilitate transmission of HIV-1 and provide new insights toward the mechanism of DC-SIGN-mediated HIV-1 transmission. Published by Elsevier Inc

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