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Effects of IL-7 and dexamethasone: Induction of CD25, the high affinity IL-2 receptor, on human CD4(+) cells

  1. Author:
    Chung, I. Y.
    Dong, H. F.
    Zhang, X.
    Hassanein, N. M. A.
    Howard, O. M. Z.
    Oppenheim, J. J.
    Chen, X.

  2. Author Address

    Ctr Canc Res, Mol Immunoregulat Lab, Ft Detrick, MD 21702 USA. SAIC Frederick Inc, Basic Res Program, Ft Detrick, MD 21702 USA. Natl Canc Inst, Expt Immunol Lab, Ft Detrick, MD 21702 USA Howard, OMZ, Ctr Canc Res, Mol Immunoregulat Lab, Ft Detrick, MD 21702 USA
    1. Year: 2004
    2. Date: NOV-DEC
  2. Journal: Cellular Immunology
    1. 232
    2. 1-2
    3. Pages: 57-63
  4. Type of Article: Article
  1. Abstract:

    Since we have previously shown that dexamethasone (Dex) enhances the proportion of murine Treg cells, we tested the effect of IL-7, a promoter of T cell survival, together with Dex oil human CD4(+)CD25(+) Treg cells in an in vitro setting. The results showed that IL-7 in concert with Dex markedly augmented the generation of CD4(+)CD25(+) T cells. To discern the origin of the induced CD4(+)CD25(+) T cells, MACS-purified CD4(+)CD25(-), and CD4(+)CD25(+) cells were cultured in the presence of Dex and/or IL-7 for 4 days. Although two thirds of CD4(+)CD25(-) T cells became CD4(+)CD25(+) T cells, they had no Suppressive activity. In contrast, the original CD4(+)CD25(+) T cells maintained Suppressive activity after Dex/IL-7 treatment, however, there was not a significant expansion ill their cell number. Dex and IL-7 did not induce additional Treg cells, but additively induced the expression of the activation marker CD25 by CD4(+)CD25(-) T cells. This combination may provide a novel means of priming CD4 T cells to respond to IL-2 and may prove useful in up-regulation of normal immune responses in immune deficient diseases. (c) 2005 Elsevier Inc. All rights reserved

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External Sources

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  2. DOI: 10.1016/j.cellimm.2005.01.011
  3. View record in Web of Science®
  4. WOS: 000229764300007

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