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Provirus load in breast milk and risk of mother-to-child transmission of human T lymphotropic virus type I

  1. Author:
    Li, H. C.
    Biggar, R. J.
    Miley, W. J.
    Maloney, E. M.
    Cranston, B.
    Hanchard, B.
    Hisada, M.

  2. Author Address

    NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Rockville, MD 20852 USA. Sci Applicat Int Corp, AIDS Vaccine Program, Viral Epidemiol Sect, Frederick, MD USA. Univ W Indies, Kingston 7, Jamaica Hisada, M, NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, 6120 Execut Blvd,EPS 8008, Rockville, MD 20852 USA
    1. Year: 2004
    2. Date: OCT 1
  2. Journal: Journal of Infectious Diseases
    1. 190
    2. 7
    3. Pages: 1275-1278
  4. Type of Article: Article
  1. Abstract:

    In a prospective study of 101 mother-child pairs in Jamaica, we examined the association of provirus load in breast milk and the risk of mother-to-child transmission of human T lymphotropic virus type I. The provirus load in breast milk was a strong predictor of risk of transmission to children ( relative risk, 2.34/quartile), after adjustment for other known risk factors. The risk of transmission increased from 4.7/1000 person-months when the provirus load in breast milk was <0.18% to 28.7/1000 person-months when it was >1.5%. Provirus detection in maternal breast milk predicted transmission months before infection in children was detected by serologic testing

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External Sources

  1. View record in Web of Science®
  2. WOS: 000223968400010

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