Skip NavigationSkip to Content
Return Return to Search Results

Cutting edge: Heterozygote advantage in autoimmune disease: Hierarchy of protection/susceptibility conferred by HLA and killer Ig-like receptor combinations in psoriatic arthritis

  1. Author:
    Nelson, G. W.
    Martin, M. P.
    Gladman, D.
    Wade, J.
    Trowsdale, J.
    Carrington, M.

  2. Author Address

    NCI Frederick, Basic Res Program, Sci Applicat Int Corp, Ft Detrick, MD 21702 USA. Toronto Western Res Inst, Toronto, ON, Canada. Toronto Western Hosp, Ctr Prognosis Studies Rheumat Dis, Toronto, ON, Canada. Univ Hlth Network, Reg HLA Lab, Toronto, ON, Canada. Univ Cambridge, Dept Pathol, Div Immunol, Cambridge, England Carrington, M, NCI Frederick, Basic Res Program, Sci Applicat Int Corp, POB B, Ft Detrick, MD 21702 USA
    1. Year: 2004
    2. Date: OCT 1
  2. Journal: Journal of Immunology
    1. 173
    2. 7
    3. Pages: 4273-4276
  4. Type of Article: Article
  1. Abstract:

    Functionally relevant combinations of HLA and killer Ig-like receptor (KIR) genotypes influence resistance to, several diseases in humans. Analysis of genetic data from such studies is challenging because it involves multiple linked and unlinked loci that exert their influence in an epistatic manner. We previously reported that subjects with certain activating receptors were susceptible to developing psoriatic arthritis (PSA), an effect that was strongest when HLA ligands for corresponding homologous inhibitory receptors were missing. In this study, we present a novel model in which susceptibility to PsA is determined by the overall balance of activating and inhibitory composite KIR-HLA genotypes. This model fits our knowledge of clonal NK cell expression of KIR and regulation of NK cell activity better than does the previous model, as reflected in a robust trend for increasing susceptibility to PsA with more activating genotypes. These data emphasize the remarkable influence of KIR/HLA combinations on this, disease

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000224072600004

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel