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A one-step synthesis of N-alpha-Fmoc-4-O-[O ',O ''-di-tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine from commercially available starting material

  1. Author:
    Kang, S. U.
    Burke, T. R.

  2. Author Address

    NCI, Med Chem Lab, Canc Res Ctr, NIH, Frederick, MD 21702 USA Burke, TR, NCI, Med Chem Lab, Canc Res Ctr, NIH, Frederick, MD 21702 USA
    1. Year: 2004
    2. Date: NOV 15
  2. Journal: Tetrahedron Letters
    1. 45
    2. 47
    3. Pages: 8611-8613
  4. Type of Article: Article
  1. Abstract:

    A one-step high yield synthesis from commercially available starting material is reported for the novel phosphotyrosyl mimetic, N-alpha-Fmoc-4-O-[O',O"-di-tert-butyl-2-(2-fluoromalonyl)]-L-tyrosine. The conditions employed for this transformation may also be applicable for the direct electrophilic fluorination of other N-alpha-Fmoc-protected amino acids. Published by Elsevier Ltd

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External Sources

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  2. DOI: 10.1016/j.tetlet.2004.09.163
  3. View record in Web of Science®
  4. WOS: 000224865600003

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