Skip NavigationSkip to Content
Return Return to Search Results

Mutational Analysis of Human Prothymosin Alpha Reveals a Bipartite Nuclear Localization Signal

  1. Author:
    Rubtsov, Y. P.
    Zolotukhin, A. S.
    Vorobjev, I. A.
    Chichkova, N. V.
    Pavlov, N. A.
    Karger, E. M.
    Evstafieva, A. G.
    Felber, B. K.
    Vartapetian, A. B.

  2. Author Address

    Vartapetian AB MOSCOW MV LOMONOSOV STATE UNIV BELOZERSKY INST PHYSICOCHEM BIOL MOSCOW 119899 RUSSIA MOSCOW MV LOMONOSOV STATE UNIV BELOZERSKY INST PHYSICOCHEM BIOL MOSCOW 119899 RUSSIA NCI FREDERICK CANC RES & DEV CTR ABL BASIC RES PROGRAM FREDERICK, MD 21701 USA
    1. Year: 1997
  2. Journal: Febs Letters
    1. 413
    2. 1
    3. Pages: 135-141
  4. Type of Article: Article
  1. Abstract:

    Mutants of human prothymosin alpha with impaired ability to inhibit yeast Saccharomyces cerevisiae. cerevisiae cell growth were characterized, Two types of prothymosin alpha-inactivating mutations were observed, Mutations that belong to the first type compromised the nuclear entry of prothymosin alpha by affecting its nuclear localization signal. Analysis of subcellular distribution of GFP-prothymosin alpha fusions revealed a bipartite nuclear localization signal that is both necessary and sufficient for nuclear import of the protein in human cells, Mutations of the second type abrogated the inhibitory action of prothymosin alpha through an unknown mechanism, without influencing the nuclear import of the protein. (C) 1997 Federation of European Biochemical Societies. [References: 34]

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel