Skip NavigationSkip to Content
Return Return to Search Results

Distinct and nonredundant in vivo functions of TNF produced by T cells and macrophages/neutrophils: Protective and deleterious effects

  1. Author:
    Grivennikov, S. I.
    Tumanov, A. V.
    Liepinsh, D. J.
    Kruglov, A. A.
    Marakusha, B. I.
    Shakhov, A. N.
    Murakami, T.
    Drutskaya, L. N.
    Forster, I.
    Clausen, B. E.
    Tessarollo, L.
    Ryffel, B.
    Kuprash, D. V.
    Nedospasov, S. A.

  2. Author Address

    Russian Acad Sci, VA Engelhardt Mol Biol Inst, Lab Mol Immunol, Moscow 119991, Russia. Belozersky Inst Physicochem Biol, Moscow 119991, Russia. NCI, Canc Res Ctr, Mol Immunoregulat Lab, Frederick, MD 21702 USA. NCI, Canc Res Ctr, Mouse Genet Program, Frederick, MD 21702 USA. SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA. Russian Acad Med Sci, Gamaleya Inst Epidemiol & Microbiol, Moscow 123098, Russia. Tech Univ Munich, Inst Med Microbiol Immunol & Hyg, D-81675 Munich, Germany. Univ Amsterdam, Acad Med Ctr, Dept Cell Biol & Histol, NL-1105 AZ Amsterdam, Netherlands. CNRS, Inst Transgenose, IEM, F-45071 Orleans, France Nedospasov, SA, Russian Acad Sci, VA Engelhardt Mol Biol Inst, Lab Mol Immunol, 32 Vavilov Str, Moscow 119991, Russia
    1. Year: 2005
    2. Date: JAN
  2. Journal: Immunity
    1. 22
    2. 1
    3. Pages: 93-104
  4. Type of Article: Article
  1. Abstract:

    Tumor necrosis factor (TNF, TNFalpha) is implicated in various pathophysiological processes and can be either protective, as in host defense, or deleterious, as in autoimmunity or toxic shock. To uncover the in vivo functions of TNF produced by different cell types, we generated mice with TNF ablation targeted to various leukocyte subsets. Systemic TNF in response to lipopolysaccharide was produced mainly by macrophages and neutrophils. This source of TNF was indispensable for resistance to an intracellular pathogen, Listeria, whereas T-cell-derived TNF was important for protection against high bacterial load. Additionally, both T-cell-derived TNF and macrophage-derived TNF had critical and nonredundant functions in the promotion of autoimmune hepatitis. Our data suggest that T-cell-specific TNF ablation may provide a therapeutic advantage over systemic blockade

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1016/j.immuni.2004.11.016
  3. View record in Web of Science®
  4. WOS: 000226682900010

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel