Skip NavigationSkip to Content
Return Return to Search Results

Cholesterol dependence of HTLV-I infection

  1. Author:
    Wielgosz, M. M.
    Rauch, D. A.
    Jones, K. S.
    Ruscetti, F. W.
    Ratner, L.

  2. Author Address

    Washington Univ, Sch Med, Dept Med & Mol Microbiol, St Louis, MO 63110 USA. Natl Canc Inst, Basic Res Lab, Frederick, MD 21702 USA Ratner, L, Washington Univ, Sch Med, Dept Med & Mol Microbiol, Box 8069,660 S Euclid Ave, St Louis, MO 63110 USA
    1. Year: 2005
    2. Date: JAN
  2. Journal: Aids Research and Human Retroviruses
    1. 21
    2. 1
    3. Pages: 43-50
  4. Type of Article: Article
  1. Abstract:

    Cholesterol- rich plasma membrane microdomains are important for entry of many viruses, including retroviruses. Depletion of cholesterol with 2- hydroxypropyl- beta- cyclodextrin inhibits entry of human T cell leukemia virus type I ( HTLV- 1) and HTLV- I envelope pseudotyped lentivirus particles. Using a soluble fusion protein of the HTLV- I surface envelope protein with the immunoglobulin Fc domain, the HTLV- I receptor was found to colocalize with a raft- associated marker and to cluster in specific plasma membrane microdomains. Depletion of cholesterol did not alter receptor binding activity, suggesting a requirement for cholesterol in a postbinding virus entry step

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1089/aid.2005.21.43
  3. View record in Web of Science®
  4. WOS: 000226832200006

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel