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Weak palindromic consensus sequences are a common feature found at the integration target sites of many retroviruses

  1. Author:
    Wu, X. L.
    Li, Y.
    Crise, B.
    Burgess, S. M.
    Munroe, D. J.

  2. Author Address

    NCI, Lab Mol Technol, Sci Applicat Int Corp, Frederick, MD 21701 USA. NCI, AIDS Vaccine Program, Sci Applicat Int Corp, Frederick, MD 21701 USA. NHGRI, Genome Technol Branch, NIH, Bethesda, MD 20892 USA Wu, XL, NCI, Lab Mol Technol, Sci Applicat Int Corp, 915 Toll HOuse Ave, Frederick, MD 21701 USA
    1. Year: 2005
    2. Date: APR
  2. Journal: Journal of Virology
    1. 79
    2. 8
    3. Pages: 5211-5214
  4. Type of Article: Article
  1. Abstract:

    Integration into the host genome is one of the hallmarks of the retroviral life cycle and is catalyzed by virus-encoded integrases. While integrase has strict sequence requirements for the viral DNA ends, target site sequences have been shown to be very diverse. We carefully examined a large number of integration target site sequences from several retroviruses, including human immunodeficiency virus type 1, simian immunodeficiency virus, murine leukemia virus, and avian sarcoma-leukosis virus, and found that a statistical palindromic consensus, centered on the virus-specific duplicated target site sequence, was a common feature at integration target sites for these retroviruses

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External Sources

  1. View record in Web of Science®
  2. WOS: 000228073700063

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