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Dynamics of the antiviral activity of N-methanocarbathymidine against herpes simplex virus type 1 in cell culture

  1. Author:
    Huleihel, M.
    Talishanisky, M.
    Ford, H.
    Marquez, V. E.
    Kelley, J. A.
    Johns, D. G.
    Agbaria, R.

  2. Author Address

    Ben Gurion Univ Negev, Inst Appl Biosci, IL-84105 Beer Sheva, Israel. NCI, Med Chem Lab, Ctr Canc Res, NIH, Frederick, MD 21702 USA. Ben Gurion Univ Negev, Dept Clin Pharmacol, IL-84105 Beer Sheva, Israel Huleihel, M, Ben Gurion Univ Negev, Inst Appl Biosci, POB 653, IL-84105 Beer Sheva, Israel
    1. Year: 2005
    2. Date: MAY
  2. Journal: International Journal of Antimicrobial Agents
    1. 25
    2. 5
    3. Pages: 427-432
  4. Type of Article: Article
  1. Abstract:

    N-Methanocarbathymidine [(N)-MCT], a thymidine analogue, exhibits potent activity in cell culture against herpes simplex virus I (HSV-1). (N)-MCT showed higher antiviral activity than ganciclovir (GCV). Continuous treatment of Vero cells with (N)-MCT immediately or 10 h post-infection (p.i.) fully prevented the development of viral infection. However, when infected cells were treated with (N)-MCT at 12 h p.i., there was only a partial inhibition (ca. 50%). Additionally, continuous treatment of infected cells with (N)-MCT for about 48 h was sufficient to achieve full prevention of viral infection without further treatment. These findings suggest the complete loss of herpes simplex thymidine kinase (HSV-tk) activity occurs after 48 h of treatment with (N)-MCT. This study helps to understand the mechanism and dynamics of antiHSV activity of (N)-MCT, which is necessary for its future development as an antiviral drug. (C) 2005 Published by Elsevier B.V. and the International Society of Chemotherapy

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External Sources

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  2. DOI: 10.1016/j.ijantimicag.2005.01.013
  3. View record in Web of Science®
  4. WOS: 000229381700011

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