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Sensitive drug-resistance assays reveal long-term persistence of HIV-1 variants with the K103N Nevirapine (NVP) resistance mutation in some women and infants after the administration of single-dose NVP: HIVNET 012

  1. Author:
    Flys, T.
    Nissley, D. V.
    Claasen, C. W.
    Jones, D.
    Shi, C. J.
    Guay, L. A.
    Musoke, P.
    Mmiro, F.
    Strathern, J. N.
    Jackson, J. B.
    Eshleman, J. R.
    Eshleman, S. H.

  2. Author Address

    Johns Hopkins Med Inst, Dept Pathol, Baltimore, MD 21205 USA. Sci Applicat Int Corp, Gene Regulat & Chromosome Biol Lab, Reverse Transcript & Mol Biol Sect, Basic Res Program, Frederick, MD USA. NCI, Frederick, MD 21701 USA. Makerere Univ, Dept Paediat, Kampala, Uganda. Makerere Univ, Dept Obstet & Gynaecol, Kampala, Uganda Eshleman, SH, Johns Hopkins Med Inst, Dept Pathol, Ross Bldg 646,720 Rutland Ave, Baltimore, MD 21205 USA
    1. Year: 2005
    2. Date: JUL 1
  2. Journal: Journal of Infectious Diseases
    1. 192
    2. 1
    3. Pages: 24-29
  4. Type of Article: Article
  1. Abstract:

    Background. The HIV Network for Prevention Trials (HIVNET) 012 trial showed that NVP resistance (NVPR) emerged in some women and children after the administration of single-dose nevirapine (SD-NVP). We tested whether K103N-containing human immunodeficiency virus (HIV)-1 variants persisted in women and infants 1 year or more after the administration of SD-NVP.Methods. We analyzed samples from 9 women and 5 infants in HIVNET 012 who had NVPR 6-8 weeks after the administration of SD-NVP. Samples were analyzed with the ViroSeq system and with 2 sensitive resistance assays, LigAmp and TyHRT.Results. ViroSeq detected the K103N mutation in 8 of 9 women and in 2 of 5 infants. LigAmp detected the K103N mutation at low levels in 8 of 9 women and in 4 of 5 infants. K103N was not detected by ViroSeq 12 24 months after the administration of SD-NVP but was detected by LigAmp in 3 of 9 women and in 1 of 5 infants. K103N was also detected in those samples by use of the TyHRT assay.Conclusions. K103N-containing variants persist in some women and infants for 1 year or more after the administration of SD-NVP. Sensitive resistance assays may provide new insight into the impact of antiretroviral drug exposure on HIV-1 evolution

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External Sources

  1. View record in Web of Science®
  2. WOS: 000229795300006

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