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Conversion of in Vitro Cultured Human Monocytes Into Effective Presenters of an Her2/Neu-Encoded Ctl Peptide Epitope

  1. Author:
    Wasserman, K.
    Corsi, M. M.
    Szekely, L.
    Kono, K.
    Maes, H. H.
    Kiessling, R.

  2. Author Address

    Wasserman K NCI FREDERICK CANC RES & DEV CTR EXPT IMMUNOL LAB DIV BASIC SCI FREDERICK, MD 21702 USA UNIV MILAN FAC MED INST GEN PATHOL MILAN ITALY KAROLINSKA INST CTR MICROBIOL & TUMOR BIOL MTC STOCKHOLM SWEDEN YAMANASHI MED UNIV DEPT SURG 1 YAMANASHI JAPAN KAROLINSKA HOSP RADIUM HEMMET DEPT ONCOL S-10401 STOCKHOLM SWEDEN
    1. Year: 1997
  2. Journal: Scandinavian Journal of Immunology
    1. 45
    2. 6
    3. Pages: 678-682
  4. Type of Article: Article
  1. Abstract:

    Tumour-derived peptides have been surveyed, in a variety of systems, for their ability to elicit cytokine release from class I restricted T cells, Analogous studies on ovarian carcinoma have employed the antigen-processing defective T2 cell line. Purified dendritic cells (DC) have been reported to act as highly effective APC. A facile method was developed whereby DC-like cells were generated from monocyte precursors, Herein, evidence is presented suggesting DC-like cells are superior to T?I with respect to their ability to present a defined CTL epitope associated with ovarian carcinoma. [References: 34]

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