Skip NavigationSkip to Content
Return Return to Search Results

Engineering DNA topology with locked nucleosides: A structural study

  1. Author:
    Maderia, M.
    Wu, J.
    Bax, A.
    Shenoy, S.
    O'Keefe, B.
    Marquez, V. E.
    Barchi, J. J.

  2. Author Address

    NCI, Med Chem Lab, Ctr Canc Res, Frederick, MD 21702 USA. NIDDK, Chem Phys Lab, Bethesda, MD 20892 USA. NCI, Lab Drug Discovery Res, Ctr Canc Res, Frederick, MD 21702 USA Barchi, JJ, NCI, Med Chem Lab, Ctr Canc Res, Frederick, MD 21702 USA
    1. Year: 2005
  2. Journal: Nucleosides Nucleotides & Nucleic Acids
    1. 24
    2. 5-7, Sp. Iss.
    3. Pages: 687-690
  4. Type of Article: Article
  1. Abstract:

    DNA dodecamers modified with nucleotide building blocks based on a bicyclo[3.1.0]hexane system that effectively locks the ribose template into an RNA-like or North (N) conformation were analyzed by various biophysical techniques including high field nuclear magnetic resonance (NMR). Replacement of either one or both of the center thymidines in the Dickerson Drew dodecamer (CGCGAAT*T*CGCG) caused a progressive shift in the bending propensity of the double helix as shown by a newly developed rapid technique that compares the residual dipolar coupling (RDC) values of the modified duplexes with those previously determined for the native DNA

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000232473500070

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel