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Risk for HIV-1 infection associated with a common CXCL12 (SDF1) polymorphism and CXCR4 variation in an African population

  1. Author:
    Petersen, D. C.
    Glashoff, R. H.
    Shrestha, S.
    Bergeron, J.
    Laten, A.
    Gold, B.
    van Rensburg, E. J.
    Dean, M.
    Hayes, V. M.

  2. Author Address

    St Vincents Hosp, Garvan Inst Med Res, Canc Res Program, Darlinghurst, NSW 2010, Australia. Univ Stellenbosch, Tygerberg Med Sch, Dept Med Virol, ZA-7600 Stellenbosch, South Africa. Univ Stellenbosch, Tygerberg Med Sch, Dept Urol, ZA-7600 Stellenbosch, South Africa. Natl Canc Inst, Lab Genom Divers, Frederick, MD USA. Sci Applicat Int Corp, Basic Res Program, Frederick, MD USA. Univ Alabama, Sch Publ Hlth, Dept Epidemiol, Birmingham, AL 35294 USA. Univ Pretoria, Dept Med Virol, ZA-0002 Pretoria, South Africa Hayes, VM, St Vincents Hosp, Garvan Inst Med Res, Canc Res Program, 384 Victoria St, Darlinghurst, NSW 2010, Australia
    1. Year: 2005
    2. Date: DEC 15
  2. Journal: Jaids-Journal of Acquired Immune Deficiency Syndromes
    1. 40
    2. 5
    3. Pages: 521-526
  4. Type of Article: Article
  1. Abstract:

    CXC chemokine ligand 12 (CXCL 12), or stromal cell-derived factor 1 (SDF1), is file only known natural ligand for the HIV-1 coreceptor, CXC chemokine receptor 4 (CXCR4). A single nucleotide polymorphism (SNP) in the CXCL12 gene (SDF1-3'A) has been associated with disease progression to AIDS in sonic studies, but not others. Mutations in the CXCR4 gene are generally rare and have not been implicated in HIV-1/AIDS pathogenesis. This Study analyzed the SDF1-3'A SNP and performed mutation screening for polymorphic markers in the CXCR4 gene to determine the presence or absence of significant associations with susceptibility to HIV-1 infection. The study consisted of 257 HIV-1-seropositive patients and 113 HIV-1-seronegative controls representing a sub-Saharan African population belonging to the Xhosa ethnic group of south Africa. The SDF1-3'A SNP was associated with ail increased risk for HIV-1 infection (P = 0.0319) whereas no significant association was observed between the Occurrence of the SDF1-3'A SNP and increased or decreased plasma levels of CXCL12. Comprehensive Mutation analysis of the CXCR4 gene confirmed a high degree of genetic conservation within the coding region of this ancient Population

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External Sources

  1. View record in Web of Science®
  2. WOS: 000233694600003

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