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KSR regulation of the Raf-MEK-ERK cascade

  1. Author:
    Ritt, D. A.
    Daar, I. O.
    Morrison, D. K.

  2. Author Address

    NCI, Lab Prot Dynam & Signaling, Frederick, MD 21701 USA Ritt, DA, NCI, Lab Prot Dynam & Signaling, Frederick, MD 21701 USA
    1. Year: 2006
  2. Book Title: Regulators and Effectors of Small Gtpases: Ras Family
  3. Series Title: Methods in Enzymology
  4. Elsevier Academic Press Inc
  5. San Diego
    1. 407
    2. Pages: 224-237
  7. Type of Work: Review
  8. ISBN: 0076-6879
  1. Abstract:

    Kinase suppressor of Ras (KSR) is a conserved component of the Ras pathway that functions as a molecular scaffold to enhance signaling between the core kinase components of the ERK cascade-Raf, MEK, and ERK. KSR interacts constitutively with MEK and translocates from the cytosol to the plasma membrane on Ras activation. At the membrane, KSR coordinates the assembly of a multiprotein complex containing Raf, MEK, and ERK and facilitates signal transmission from Raf to MEK and ERK. In this chapter, we will describe methods for assessing KSR function in response to Ras pathway activation. Protocols will be included that examine the ERK scaffolding activity and subcellular localization of KSR

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External Sources

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  2. DOI: 10.1016/S0076-6879(05)07019-9
  3. View record in Web of Science®
  4. WOS: 000237082800019

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