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Redefining the common insertion site

  1. Author:
    Wu, X. L.
    Luke, B. T.
    Burgess, S. M.

  2. Author Address

    NHGRI, Dev Genom Sect, Genome Technol Branch, NIH, Bethesda, MD 20892 USA. NCI, Lab Mol Technol, Sci Applicat Int Corp Frederick, NIH, Frederick, MD 21701 USA. NCI, Adv Biomed Comp Ctr, Sci Applicat Int Corp Frederick, NIH, Frederick, MD 21701 USA Burgess, SM, NHGRI, Dev Genom Sect, Genome Technol Branch, NIH, Bldg 50,Rm 5537,MSC 8004,50 South Dr, Bethesda, MD 20892 USA
    1. Year: 2006
    2. Date: JAN 20
  2. Journal: Virology
    1. 344
    2. 2
    3. Pages: 292-295
  4. Type of Article: Article
  1. Abstract:

    Retroviral mutagenesis has been used as a powerful tool to discover genes involved in oncogenesis through a technique called Common Insertion Site (CIS) analysis where tumors are induced by proviral integrations and the genomic loci of the proviruses are identified. A fundamental assumption made in this analysis is that multiple proviral insertions in close proximity occurring more frequently than would be predicted randomly provides evidence that the genes near the integrations are involved in the formation of the tumors. We demonstrate here using data derived from MLV integrations not put under selection for tumor induction that CIS analysis as currently defined is often not a sufficient argument for a gene's significance in tumorigenesis. (C) 2005 Elsevier Inc. All rights reserved

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External Sources

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  2. DOI: 10.1016/j.virol.2005.08.047
  3. View record in Web of Science®
  4. WOS: 000234776900005

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