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Energy cost of infection burden: An approach to understanding the dynamics of host-pathogen interactions

  1. Author:
    Romanyukha, A. A.
    Rudnev, S. G.
    Sidorov, I. A.

  2. Author Address

    NCI, Canc Res Ctr, Nanobiol Program, CCR,NIH, Frederick, MD 21702 USA. Russian Acad Sci, Inst Numer Math, Moscow 119991, Russia.;Sidorov, IA, NCI, Canc Res Ctr, Nanobiol Program, CCR,NIH, Bldg 469-110,POB B, Frederick, MD 21702 USA.;eburg@inm.ras.ru rudnev@inm.ras.ru sidorovi@ncifcrf.gov
    1. Year: 2006
    2. Date: Jul
  2. Journal: Journal of Theoretical Biology
    1. 241
    2. 1
    3. Pages: 1-13
  4. Type of Article: Article
  5. ISSN: 0022-5193
  1. Abstract:

    A mathematical model of long-term immune defense against infection Was used to estimate the energy involved in the principal processes of immune resistance during periods of health and infection. From these values. an optimal level of energy was determined for immune response depending on infection burden. The present findings suggest that weak but prevalent pathogens lead to latent or chronic infection, whereas more virulent but less prevalent pathogens result in acute infection. This energy-based approach offers insight into the mechanisms of immune system adaptation leading to the development of chronic infectious diseases and immune deficiencies. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.jtbi.2005.11.004
  3. View record in Web of Science®
  4. WOS: 000238714600001

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