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Arsenicals in maternal and fetal mouse tissues after gestational exposure to arsenite

  1. Author:
    Devesa, V.
    Adair, B. M.
    Liu, J.
    Waalkes, M. P.
    Diwan, B. A.
    Styblo, M.
    Thomas, D. J.

  2. Author Address

    US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Expt Toxicol Div, Res Triangle Pk, NC 27711 USA. Univ N Carolina, Ctr Environm Med Asthma & Lung Biol, Chapel Hill, NC USA. NIEHS, Comparat Carcinogenesis Lab, NCI, Res Triangle Pk, NC 27709 USA. SAIC Frederick, Basic Res Program, Frederick, MD USA. Univ N Carolina, Sch Publ Hlth, Dept Nutr, Chapel Hill, NC 27599 USA.;Thomas, DJ, US EPA, Off Res & Dev, Natl Hlth & Environm Effects Res Lab, Expt Toxicol Div, Mail Drop B143-1,109 Alexander Dr, Res Triangle Pk, NC 27711 USA.;thomas.david@epa.gov
    1. Year: 2006
    2. Date: Jul
  2. Journal: Toxicology
    1. 224
    2. 1-2
    3. Pages: 147-155
  4. Type of Article: Article
  5. ISSN: 0300-483X
  1. Abstract:

    Exposure of pregnant C3H/HeNCR mice to 42.5- or 85-ppm of arsenic as sodium arsenite in drinking water between days 8 and 18 of gestation markedly increases tumor incidence in their offspring. In the work reported here. distribution of inorganic arsenic and its metabolites, methyl arsenic and dimethyl arsenic. were determined in maternal and fetal tissues collected on gestational day 18 of these exposure regimens. Tissues were collected from three females and from associated fetuses exposed to each dosage level. Concentrations of total speciated arsenic (sum of inorganic, methyl, and dimethyl arsenic) were higher in maternal tissues than in placenta and fetal tissues; total speciated arsenic concentration in placenta exceeded those in fetal tissues. significant dosage-dependent (42.5 ppm versus 85 ppm of arsenite in drinking water) differences were found in total speciated arsenic concentrations in maternal lung (p < 0.01) and liver (p < 0.001). Total speciated arsenic concentrations did not differ significantly between dosage levels for maternal blood or for fetal lung. liver. and blood. or for placenta. Percentages of inorganic. methyl. or dimethyl arsenic in maternal or fetal tissues were not dosage-dependent. Over the range of total speciated arsenic concentrations in most maternal and fetal tissues, dimethyl arsenic was the most abundant arsenical. However. in maternal liver at the highest total speciated arsenic concentration, inorganic arsenic was the most abundant arsenical. suggesting that a high tissue burden of arsenic affected formation or retention of methylated species in this organ. Tissue concentration-dependent processes Could affect kinetics of transfer of inorganic arsenic or its metabolites from mother to fetus. Published by Elsevier Ireland Ltd.

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  2. DOI: 10.1016/j.tox.2006.04.041
  3. View record in Web of Science®
  4. WOS: 000239031400016

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