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MR assessment of changes of tumor in response to hyperbaric oxygen treatment

  1. Author:
    Matsumoto, K.
    Bernardo, M.
    Subramanian, S.
    Choyke, P.
    Mitchell, J. B.
    Krishna, M. C.
    Lizak, M. J.

  2. Author Address

    NCI, Radiat Biol Branch, Canc Res Ctr, NIH, Bethesda, MD 20892 USA. NCI, Mol Imaging Program, Canc Res Ctr, Bethesda, MD 20892 USA. SAIC Frederick, Res Technol Program, Frederick, MD USA. NINDS, MRI Res Facil, Bethesda, MD 20892 USA.;Krishna, MC, NCI, Radiat Biol Branch, Canc Res Ctr, NIH, Bldg 10,Room B3B69, Bethesda, MD 20892 USA.;murali@helix.nih.gov
    1. Year: 2006
    2. Date: Aug
  2. Journal: Magnetic Resonance in Medicine
    1. 56
    2. 2
    3. Pages: 240-246
  4. Type of Article: Article
  5. ISSN: 0740-3194
  1. Abstract:

    Enhancement of image intensity, using the T-1-weighted spoiled gradient-echo (SPGR) sequence, was measured in SCC tumor implanted in the flank of C3H mice while they were subjected to several types of oxygenation challenges inside a hyperbaric chamber designed and constructed to fit in an MRI resonator. The central portions of the tumor gave a positive enhancement, while the periphery showed signal reduction during both normobaric (NBO) and hyperbaric (HBO) oxygen challenges. In the contralateral normal leg, nearly 70% of the region showed a decrease in intensity, and the rest showed a positive enhancement. The positive signal enhancement was markedly greater under HBO compared to NBO. Calculated R-1, R-2, and M-0 maps from multivariate fitting of images acquired by a multislice multiecho (MSME) sequence with variable TR before, during, and after HBO treatment confirm that the source of SPGR signal enhancement in the tumor is associated with shortening of T-1.

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External Sources

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  2. DOI: 10.1002/mrm.20961
  3. View record in Web of Science®
  4. WOS: 000239465500002

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