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The livestock photosensitizer, phytoporphyrin (phylloerythrin), is a substrate of the ATP-binding cassette transporter ABCG2

  1. Author:
    Robey, R. W.
    Fetsch, P. A.
    Polgar, O.
    Dean, M.
    Bates, S. E.

  2. Author Address

    NCI, Med Oncol Branch, Canc Res Ctr, Bethesda, MD 20892 USA. NCI, Pathol Lab, Canc Res Ctr, Bethesda, MD 20892 USA. NCI, Human Genet Sect, Lab Genom Divers, Frederick, MD 21702 USA.;Robey, RW, NCI, Med Oncol Branch, Canc Res Ctr, Bldg 10,Room 13N240B,10 Ctr Dr,MSC 1903, Bethesda, MD 20892 USA.;robeyr@mail.nih.gov
    1. Year: 2006
    2. Date: Dec
  2. Journal: Research in Veterinary Science
    1. 81
    2. 3
    3. Pages: 345-349
  4. Type of Article: Article
  5. ISSN: 0034-5288
  1. Abstract:

    Hepatogenous photosensitization occurs in livestock following damage to the liver or biliary apparatus that results in impaired excretion of phytoporphyrin (phylloerythrin), a photo sensitizer. Based on earlier observations that porphyrin-based photosensitizers are substrates of the ATP-binding cassette transporter ABCG2, we examined the ability of the hepatic transporters ABCB1 (P-glycoprotein) and ABCG2 to transport phytoporphyrin. Transport of phytoporphyrin was blocked by the ABCG2-specific inhibitor fumitremorgin C (FTC) in human embryonic kidney cells transfected with full length human ABCG2, while no transport by cells transfected with human ABCB1 was noted. FTC-inhibited transport of phytoporphyrin was also demonstrated in ABCG2-expressing LLC-PK1 pig kidney cells, consistent with the idea that the pig orthologue, like human ABCG2, transports the photo sensitizer. ABCG2 expression was confirmed by immunohistochemistry in the hepatocytes of cow, pig and sheep livers. We conclude that phytoporphyrin is a substrate for ABCG2 and that the transporter is likely responsible for its biliary excretion. Published by Elsevier Ltd.

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External Sources

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  2. DOI: 10.1016/j.rvsc.2006.04.003
  3. View record in Web of Science®
  4. WOS: 000240951000009

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