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Dendritic-cell interactions with HIV: infection and viral dissemination

  1. Author:
    Wu, L.
    KewalRamani, V. N.

  2. Author Address

    Med Coll Wisconsin, Dept Microbiol & Mol Genet, Milwaukee, WI 53226 USA. Natl Canc Inst, HIV Drug Resistance Program, NIH, Frederick, MD 21702 USA.;Wu, L, Med Coll Wisconsin, Dept Microbiol & Mol Genet, 8701 Watertown Plank Rd, Milwaukee, WI 53226 USA.;liwu@mcw.edu
    1. Year: 2006
    2. Date: Nov
  2. Journal: Nature Reviews Immunology
    1. 6
    2. 11
    3. Pages: 859-868
  4. Type of Article: Review
  5. ISSN: 1474-1733
  1. Abstract:

    Dendritic cells (DCs) are crucial for the generation and the regulation of adaptive immunity. Because DCs have a pivotal role in marshalling immune responses, HIV has evolved ways to exploit DCs, thereby facilitating viral dissemination and allowing evasion of antiviral immunity. Defining the mechanisms that underlie cell-cell transmission of HIV and understanding the role of DCs in this process should help us in the fight against HIV infection. This Review highlights the latest advances in our understanding of the interactions between DCs and HIV, focusing on the mechanisms of DC-mediated viral dissemination.

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External Sources

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  2. DOI: 10.1038/nri1960
  3. View record in Web of Science®
  4. WOS: 000241574000016

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