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The LRC haplotype project: a resource for killer immunoglobulin-like receptor-linked association studies

  1. Author:
    Horton, R.
    Coggill, P.
    Miretti, M. M.
    Sambrook, J. G.
    Traherne, J. A.
    Ward, R.
    Sims, S.
    Palmer, S.
    Sehra, H.
    Harrow, J.
    Rogers, J.
    Carrington, M.
    Trowsdale, J.
    Beck, S.

  2. Author Address

    Wellcome Trust Sanger Inst, Cambridge CB10 1SA, England. Univ Cambridge, Dept Pathol, Dept Immunol, Cambridge CB2 1QP, England. NCI, SAIC Frederick Inc, Lab Genome Diver, Frederick, MD 21702 USA.;Beck, S, Wellcome Trust Sanger Inst, Genome Campus, Cambridge CB10 1SA, England.;beck@sanger.ac.uk
    1. Year: 2006
    2. Date: Nov
  2. Journal: Tissue Antigens
    1. 68
    2. 5
    3. Pages: 450-452
  4. Type of Article: Article
  5. ISSN: 0001-2815
  1. Abstract:

    There is increasing evidence for epistatic interactions between gene products (e.g. KIR) encoded within the Leukocyte Receptor Complex (LRC) with those (e.g. HLA) of the Major Histocompatibility Complex (MHC), resulting in susceptibility to disease. Identification of such associations at the DNA level requires comprehensive knowledge of the genetic variation and haplotype structure of the underlying loci. The LRC haplotype project aims to provide this knowledge by sequencing common LRC haplotypes.

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External Sources

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  2. DOI: 10.1111/j.1399-0039.2006.00697.x
  3. View record in Web of Science®
  4. WOS: 000241831800012

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