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Polymorphisms in eight host genes associated with control of HIV replication do not mediate elite control of viral replication in SIV-infected Indian rhesus macaques

  1. Author:
    Weiler, A.
    May, G. E.
    Qi, Y.
    Wilson, N.
    Watkins, D. I.

  2. Author Address

    Univ Wisconsin, Wisconsin Natl Primate Res Ctr, Madison, WI 53715 USA. Univ Wisconsin, Dept Pathol & Lab Med, Madison, WI 53715 USA. SAIC Frederick, Lab Genom Divers, NCI, Ft Detrick, MD 21702 USA.;Weiler, A, Univ Wisconsin, Wisconsin Natl Primate Res Ctr, 1223 Capitol Court, Madison, WI 53715 USA.;amweiler@wisc.edu
    1. Year: 2006
    2. Date: Dec
  2. Journal: Immunogenetics
    1. 58
    2. 12
    3. Pages: 1003-1009
  4. Type of Article: Article
  5. ISSN: 0093-7711
  1. Abstract:

    Polymorphisms in several host genes in HIV-infected individuals facilitate slow progression to AIDS. We have identified several SIV-infected Indian rhesus macaques that naturally control viral replication. We investigated whether spontaneous control of SIV in any of these animals could be explained by mutations in host genes. Such variables could confound studies of associations between MHC class I alleles and control of viral replication. We searched for polymorphisms in CCR5, CXCR6, GPR15, RANTES, IL-10, APOBEC3G, TNF-alpha, and TSG101 and looked for associations with decreased viral replication. We did not detect any correlations between plasma viral concentration and polymorphisms in host genes examined in this study. In addition, we did not find the polymorphisms present in humans in any of our macaques.

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External Sources

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  2. DOI: 10.1007/s00251-006-0166-6
  3. View record in Web of Science®
  4. WOS: 000243072900007

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