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Cutting edge: Allele-specific and peptide-dependent interactions between KIR3DL1 and HLA-A and HLA-B

  1. Author:
    Thananchai, H.
    Gillespie, G.
    Martin, M. P.
    Bashirova, A.
    Yawata, N.
    Yawata, M.
    Easterbrook, P.
    McVicar, D. W.
    Maenaka, K.
    Parham, P.
    Carrington, M.
    Dong, T.
    Rowl, -Jones

  2. Author Address

    MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford, England. Sci Applicat Int Corp, Lab Genom Delivery, NCI, Frederick, MD 21702 USA. Johns Hopkins Univ, Sch Med, Baltimore, MD 21205 USA. Stanford Univ, Dept Microbiol & Immunol, Sch Med, Stanford, CA 94305 USA. Stanford Univ, Sch Med, Dept Biol Struct, Stanford, CA 94305 USA. Huys Kings & St Thomas Sch Med, Dept HIV Genitourinary Med, London, England. NCI, Expt Immunol Lab, Frederick, MD 21702 USA. Kyushu Univ, Med Inst Bioregulat, Div Struct Biol, Fukuoka 812, Japan.;Dong, T, John Radcliffe Hosp, MRC, Human Immunol Unit, Weatherall Inst Mol Med, Oxford OX3 9DS, England.;TDong@hammer.imm.ox.ac.uk sarah.rowland-jones@ndm.ox.ac.uk
    1. Year: 2007
    2. Date: Jan
  2. Journal: Journal of Immunology
    1. 178
    2. 1
    3. Pages: 33-37
  4. Type of Article: Article
  5. ISSN: 0022-1767
  1. Abstract:

    Although it is clear that KIR3DL1 recognizes Bw4(+) HLA-B, the role of Bw4(+) HLA-A allotypes as KIR3DL1 ligands is controversial We therefore examined the hinding of tetrameric HLA-A and -B complexes, including HLA*2402, a common Bw4(+) HLA-A allotype, to KIR3DLI*001, *005, *007, and *1502 allotypes. Only Bw4(+) tetramers hound K7R3DL1. Three of four HLA-A*2402 tetramers bound one or more KIR3DL1 allotypes and all four KIR3DL1 allotypes bound to one or more HLA-A*2402 tetramers, but with different binding specificities. Only KTR3DL1*005 bound both HLA-A*2402 and HLA-B*5703 tetramers. HLA-A*2402-expressing target cells were resistant to lysis by NK cells expressing KIR3DL1*001 or *005. This study shows that HLA-A*2402 is a ligand for KIR3DL1 and demonstrates how the binding of KIR3DL1 to Bw4(+) ligands depends upon the bound peptide as well as HLA and KIR3DL1 polymorphism.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000243120900004

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