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A 1.5-Mb-resolution radiation hybrid map of the cat genome and comparative analysis with the canine and human genomes

  1. Author:
    Murphy, W. J.
    Davis, B.
    David, V. A.
    Agarwala, R.
    Schaffer, A. A.
    Wilkerson, A. J. P.
    Neelam, B.
    O'Brien, S. J.
    Menotti-Raymond, M.

  2. Author Address

    Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, College Stn, TX 77843 USA. NCI, Lab Genome Divers, Frederick, MD 21702 USA. Natl Lib Med, Informat Engn Branch, Natl Ctr Biotechnol Informat, NIH,Dept Hlth & Human Serv, Bethesda, MD 20894 USA. Natl Lib Med, Computat Biol Branch, Natl Ctr Biotechnol Informat, NIH,Dept Hlth & Human Serv, Bethesda, MD 20894 USA. NCI, Adv Biomed Comp Ctr, Frederick, MD 21702 USA.;Murphy, WJ, Texas A&M Univ, Coll Vet Med & Biomed Sci, Dept Vet Integrat Biosci, Mail Stop 4458, College Stn, TX 77843 USA.;wmurphy@cvm.tamu.edu
    1. Year: 2007
    2. Date: Feb
  2. Journal: Genomics
    1. 89
    2. 2
    3. Pages: 189-196
  4. Type of Article: Article
  5. ISSN: 0888-7543
  1. Abstract:

    We report the construction of a 1.5-Mb-resolution radiation hybrid map of the domestic cat genome. This new map includes novel microsatellite loci and markers derived from the 2X genome sequence that target previous gaps in the feline-human comparative map. Ninety-six percent of the 1793 cat markers we mapped have identifiable orthologues in the canine and human genome sequences. The updated autosomal and X-chromosome comparative maps identify 152 cat-human and 134 cat-dog hornologous synteny blocks. Comparative analysis shows the marked change in chromosomal evolution in the canid lineage relative to the felid lineage since divergence from their carnivoran ancestor. The canid lineage has a 30-fold difference in the number of interchromosomal rearrangements relative to felids, while the felid lineage has primarily undergone intrachromosomal rearrangements. We have also refined the pseudoautosomal region and boundary in the cat and show that it is markedly longer than those of human or mouse. This improved RH comparative map provides a useful tool to facilitate positional cloning studies in the feline model. (c) 2006 Elsevier Inc. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.ygeno.2006.08.007
  3. View record in Web of Science®
  4. WOS: 000243604300003

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