GLUT1 is not the primary binding receptor but is associated with cell-to-cell transmission of human T-cell leukemia virus type 1

Author:

Takenouchi, N.

Jones, K. S.

Lisinski, I.

Fugo, K.

Yao, K.

Cushman, S. W.

Ruscetti, F. W.

Jacobson, S.
Author Address

NINDS, Viral Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20982 USA. SAIC Frederick, Basic Res Program, Frederick, MD 21702 USA. NINDS, Viral Immunol Sect, Neuroimmunol Branch, NIH, Bethesda, MD 20892 USA. NINDS, Expt Diabet Metab & Nutr Sect, NIH, Bethesda, MD 20892 USA. NCI, Expt Immunol Lab, Canc Res Ctr, Frederick, MD 21702 USA.;Jacobson, S, NINDS, Viral Immunol Sect, Neuroimmunol Branch, NIH, 9000 Rockville Pike, Bethesda, MD 20982 USA.;jacobsons@ninds.nih.gov

Abstract:

GLUT1 has recently been suggested to be a binding receptor for human T-cell leukemia virus type 1 (HTLV-1). We used a novel, short-term assay to define the role of GLUT1 in cell-to-cell transmission. Although increasing cell surface levels of GLUT1 enhanced HTLV-1 transfer, efficient virus spread correlated largely with heparan sulfate proteoglycan (HSPG) expression on target cells. Moreover, since activated CD4(+) T cells and cord blood lymphocytes that are susceptible to HTLV-1 infection expressed undetectable levels of surface GLUT1, these results indicate that GLUT1 and HSPGs are important for efficient cell-to-cell transmission of HTLV-1 but raise concerns on the role of GLUT1 as the HTLV-1 primary binding receptor.

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