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Identification of a novel chromosome region, 13q21.33-q22.2, for susceptibility genes in familial chronic lymphocytic leukemia

  1. Author:
    Ng, D.
    Toure, O.
    Wei, M. H.
    Arthur, D. C.
    Abbasi, F.
    Fontaine, L.
    Marti, G. E.
    Fraumeni, J. F.
    Goldin, L. R.
    Caporaso, N.
    Toro, J. R.

  2. Author Address

    NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, Bethesda, MD 20892 USA. Sci Applicat Int Corp, Program Div Canc Epidemiol & Genet, Frederick, MD USA. NCI, Pathol Lab, Canc Res Ctr, NIH,DHHS, Bethesda, MD 20892 USA. US FDA, Flow & Image Cytometry Lab, Cellular Therapy & Tissues Branch, Div Gene & Cell Therapy,Ctr Biol Evaluat & Res, Bethesda, MD 20014 USA. WESTAT Corp, Rockville, MD 20850 USA. NCI, Off Director, Div Canc Epidemiol & Genet, NIH,DHHS, Rockville, MD USA.;Toro, JR, NCI, Genet Epidemiol Branch, Div Canc Epidemiol & Genet, NIH,Dept Hlth & Human Serv, 6120 Execut Blvd,Execut Plaza S,Rm 7012, Bethesda, MD 20892 USA.;toroj@mail.nih.gov
    1. Year: 2007
    2. Date: Feb
  2. Journal: Blood
    1. 109
    2. 3
    3. Pages: 916-925
  4. Type of Article: Article
  5. ISSN: 0006-4971
  1. Abstract:

    Chronic lymphocytic leukemia (CLL) is the most prevalent form of leukemia in adults in western countries. A genome scan of CLL-prone families revealed a lod score of one in band 13q22.1. To investigate this finding, we selected 6 CLL families consisting of 63 individuals (CLL affected, n = 19; unaffected, n = 44) for fine mapping of a 23-megabase region in 13q14.2-q22.2. Interphase fluorescence in situ hybridization (FISH) revealed 13q14 deletion in 85% (11/13) of CLL patients. Four CLL families shared a 3.68-Mb minimal region in 13q21.33-q22.2. Two asymptomatic siblings who shared the 13q2l.33q22.2 at-risk haplotype exhibited CD5+ monoclonal B-cell lymphocytosis (MBL) on flow cytometry. One of these individuals also had a 13q14 deletion by FISH. These 2 individuals with MBL shared the at-risk haplotype with their CLL-affected relatives, providing further evidence of the relationship between CLL and MBL, as well as of the biologic significance of this novel region. Using direct DNA sequencing analysis, we screened 13 genes for mutations, but no frameshift or nonsense mutations were detected. Our studies revealed that 11 of the 13 genes in the candidate region were expressed in immune tissues, supporting their functional relevance in investigations of familial CLL. In conclusion, we identified a novel candidate region that may predispose to familial CLL.

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External Sources

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  2. DOI: 10.1182/blood-2006-03-011825
  3. View record in Web of Science®
  4. WOS: 000244132800020

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