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Long-lasting decrease in viremia in macaques chronically infected with simian immunodeficiency virus SIVmac251 after therapeutic DNA immunization

  1. Author:
    von Gegerfelt, A. S.
    Rosati, M.
    Alicea, C.
    Valentin, A.
    Roth, P.
    Bear, J.
    Franchini, G.
    Albert, P. S.
    Bischofberger, N.
    Boyer, J. D.
    Weiner, D. B.
    Markham, P.
    Israel, Z. R.
    Eldridge, J. H.
    Pavlakis, G. N.
    Felber, B. K.

  2. Author Address

    NCI, Human Retrovirus Sect, Vaccine Branch, Canc Res Ctr, Frederick, MD 21702 USA. NCI, Human Retrovirus Pathogenesis Sect, Vaccine Branch, Canc Res Ctr, Frederick, MD 21702 USA. NCI, Anim Models & Retroviral Vaccines Sect, Vaccine Branch, Ctr Canc Res, Bethesda, MD 20892 USA. NCI, Biometr Res Branch, Bethesda, MD 20892 USA. Gilead Sci Inc, Foster City, CA 94404 USA. Univ Penn, Sch Med, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA. Adv BioSci Labs Inc, Kensington, MD 20895 USA. Wyeth Vaccines Res, Pearl River, NY 10965 USA.;Pavlakis, GN, NCI, Human Retrovirus Sect, Vaccine Branch, Canc Res Ctr, 1050 Boyles St,Bldg 535,Room 210, Frederick, MD 21702 USA.;pavlakis@ncifcrf.gov
    1. Year: 2007
    2. Date: Feb
  2. Journal: Journal of Virology
    1. 81
    2. 4
    3. Pages: 1972-1979
  4. Type of Article: Article
  5. ISSN: 0022-538X
  1. Abstract:

    Rhesus macaques chronically infected with highly pathogenic simian immunodeficiency virus (SIV) SIVmac251 were treated with antiretroviral drugs and vaccinated with combinations of DNA vectors expressing SIV antigens. Vaccination during therapy increased cellular immune responses. After the animals were released from therapy, the virus levels of 12 immunized animals were significantly lower (P = 0.001) compared to those of 11 animals treated with only antiretroviral drugs. Vaccinated animals showed a persistent increase in immune responses, thus indicating both a virological and an immunological benefit following DNA therapeutic vaccination. Several animals show a long-lasting decrease in viremia, suggesting that therapeutic vaccination may provide an additional benefit to antiretroviral therapy.

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External Sources

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  2. DOI: 10.1128/jvi.01990-06
  3. View record in Web of Science®
  4. WOS: 000244241400040

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