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The consequence of PRELP overexpression on skin

  1. Author:
    Grover, J.
    Lee, E. R.
    Mounkes, L. C.
    Stewart, C. L.
    Roughley, P. J.

  2. Author Address

    Shriners Hosp Children, Genet Unit, Montreal, PQ H3G 1A6, Canada. McGill Univ, Dept Surg, Montreal, PQ H3A 2T5, Canada. Shriners Hosp Children, Electron Microscopy Unit, Montreal, PQ, Canada. Natl Canc Inst, Canc & Dev Biol lab, Frederick, MD USA.;Roughley, PJ, Shriners Hosp Children, Genet Unit, 1529 Cedar Ave, Montreal, PQ H3G 1A6, Canada.;proughley@shriners.mcgill.ca
    1. Year: 2007
    2. Date: Mar
  2. Journal: Matrix Biology
    1. 26
    2. 2
    3. Pages: 140-143
  4. Type of Article: Article
  5. ISSN: 0945-053X
  1. Abstract:

    PRELP is a member of the small leucine-rich repeat proteoglycan family that is abundantly expressed in many cartilages compared to other connective tissues. To study the consequence of PRELP overexpression in tissues where it is normally expressed at low abundance, transgenic mice were generated in which the human PRELP transgene was placed under control of the CMV promoter. A connective tissue phenotype was observed in the skin, where the organization of collagen fibrils in the dermis was perturbed and the thickness of the hypodermal fat layer was diminished. (c) 2006 Elsevier B.V./Intemational Society of Matrix Biology. All rights reserved.

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External Sources

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  2. DOI: 10.1016/j.matbio.2006.10.005
  3. View record in Web of Science®
  4. WOS: 000244586700009

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