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AP-1 a target for cancer prevention

  1. Author:
    Matthews, C. P.
    Colburn, N. H.
    Young, M. R.

  2. Author Address

    NCI, Lab Canc Prevent, Frederick, MD 21702 USA.;Young, MR, NCI, Lab Canc Prevent, Frederick, MD 21702 USA.;youngm@ncifcrf.gov
    1. Year: 2007
    2. Date: Jun
  2. Journal: Current Cancer Drug Targets
    1. 7
    2. 4
    3. Pages: 317-324
  4. Type of Article: Review
  5. ISSN: 1568-0096
  1. Abstract:

    The transcription factor activator protein 1 (AP-1) plays a pivotal role in tumorigenesis. AP-1 activity is increased in multiple human tumor types. Inhibitors of AP-1 have been shown to block tumor promotion, trans formation, progression and invasion. Chronic inflammation and tumor development are linked. AP-1 may act, in part, by perpetuating the inflammatory signal. AP-1 is a recognized molecular target of many antioxidant and anti-inflammatory chem,chemopreventive compounds. This review focuses on the AP-1 family proteins as targets for chemoprevention.

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External Sources

  1. View record in Web of Science®
  2. WOS: 000246883500003

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