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Genome-wide scans for diabetic nephropathy and albuntinuria in multiethnic populations - The family investigation of nephropathy and diabetes (FIND)

  1. Author:
    Iyengar, S. K.
    Abboud, H. E.
    Goddard, K. A. B.
    Saad, M. F.
    Adler, S. G.
    Arar, N. H.
    Bowden, D. W.
    Duggirala, R.
    Elston, R. C.
    Hanson, R. L.
    Ipp, E.
    Kao, W. H. L.
    Kimmel, P. L.
    Klag, M. J.
    Knowler, W. C.
    Meoni, L. A.
    Nelson, R. G.
    Nicholas, S. B.
    Pahl, M. V.
    Parekh, R. S.
    Quade, S. R. E.
    Rich, S. S.
    Rotter, J. I.
    Scavini, M.
    Schelling, J. R.
    Sedor, J. R.
    Sehgal, A. R.
    Shah, V. O.
    Smith, M. W.
    Taylor, K. D.
    Winkler, C. A.
    Zager, P. G.
    Freedman, B. I.
    Family Invest, N.

  2. Author Address

    Case Western Reserve Univ, Dept Epidemiol & Biostat, FIND Genet Anal & Data Coordinating Ctr, Cleveland, OH 44106 USA. Univ Texas, Hlth Sci Ctr, San Antonio, TX USA. Univ Calif Los Angeles, Harbor Med Ctr, Los Angeles, CA 90024 USA. Wake Forest Univ, Winston Salem, NC 27109 USA. NIDDK, Phoenix, AZ USA. Johns Hopkins Univ, Baltimore, MD USA. NIDDK, Program Off, Bethesda, MD USA. Univ New Mexico, Albuquerque, NM 87131 USA. NCI, Lab Genom Divers, Frederick, MD 21701 USA.;Iyengar, SK, Case Western Reserve Univ, Dept Epidemiol & Biostat, FIND Genet Anal & Data Coordinating Ctr, Wolstein Res Bldg,Room 1315,10900 Euclid Ave, Cleveland, OH 44106 USA.;ski@case.edu
    1. Year: 2007
    2. Date: Jun
  2. Journal: Diabetes
    1. 56
    2. 6
    3. Pages: 1577-1585
  4. Type of Article: Article
  5. ISSN: 0012-1797
  1. Abstract:

    The Family Investigation of Nephropathy and Diabetes (FIND) was initiated to map genes underlying susceptibility to diabetic nephropathy. A total of 11 centers participated under a single collection protocol to recruit large numbers of diabetic sibling pairs concordant and discordant for diabetic nephropathy. We report the findings from the first-phase genetic analyses in 1,227 participants from 378 pedigrees of European-American, African-American, Mexican-American, and American Indian descent recruited from eight centers. Model-free linkage analyses, using a dichotomous definition for diabetic nephropathy in 397 sibling pairs, as well as the quantitative trait urinary albumin-to-creatinine ratio (ACR), were performed using the Haseman-Elston linkage test on 404 microsatellite markers. The strongest evidence of linkage to the diabetic nephropathy trait was on chromosomes 7q21.3, 10p15.3, 14q23.1, and 18q22.3. In ACR (883 diabetic sibling pairs), the strongest linkage signals were on chromosomes 2q14.1, 7q21.1, and 15q26.3. These results confirm regions of linkage to diabetic nephropathy on chromosomes 7q, 10p, and 18q from prior reports, making it important that genes underlying these peaks be evaluated for their contribution to nephropathy susceptibility. Large family collections consisting of multiple members with diabetes and advanced nephropathy are likely to accelerate the identification of genes causing diabetic nephropathy, a life-threatening complication of diabetes.

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External Sources

  1. View Full Text
  2. DOI: 10.2337/db06-1154
  3. View record in Web of Science®
  4. WOS: 000246930000011

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