Skip NavigationSkip to Content
Return Return to Search Results

Continuous wave EPR oximetric imaging at 300 MHz using Radiofrequency power saturation effects

  1. Author:
    Hama, Y.
    Matsumoto, K. I.
    Murugesan, R.
    Subramanian, S.
    Devasahayam, N.
    Koscielniak, J. W.
    Hyodo, F.
    Cook, J. A.
    Mitchell, J. B.
    Krishna, M. C.

  2. Author Address

    NCI, Ctr Canc Res, Radiat Biol Branch, Bethesda, MD 20892 USA. Natl Inst Radiol Sci, Heavy Ion Radiobiol Res Grp, Res Ctr Charged Particle Therapy, Chiba 260, Japan. Madurai Kamaraj Univ, Sch Chem, Madurai 625021, Tamil Nadu, India. NCI, Ctr Canc Res, Lab Proteom & Anal Technol, Frederick, MD 21701 USA.;Krishna, MC, NCI, Ctr Canc Res, Radiat Biol Branch, Bethesda, MD 20892 USA.;murali@helix.nih.gov
    1. Year: 2007
    2. Date: Oct
  2. Journal: Antioxidants & Redox Signaling
    1. 9
    2. 10
    3. Pages: 1709-1716
  4. Type of Article: Article
  5. ISSN: 1523-0864
  1. Abstract:

    A novel continuous wave (CW), radiofrequency (RF), electron paramagnetic resonance (EPR) oximetric imaging technique is proposed, based on the influence of oxygen concentration on the RF power saturation of the EPR resonance. A linear relationship is demonstrated between the partial oxygen pressure (PO2) and the normalized signal intensity (I-N), defined as, I-N = (I-HP - I-LP)/I-LP, where I-LP and I-HP refer to signal intensities at low (P-L) and high (P-H) RF power levels, respectively. A formula for the determination Of PO2, derived on the basis of the experimental results, reliably estimated various oxygen concentrations in a five-tube phantom. This new technique was time-efficient and also avoided the missing angle problem associated with conventional spectral-spatial CW EPR oximetric imaging. In vivo power saturation oximetric imaging in a tumor bearing mouse clearly depicted the hypoxic foci within the tumor.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1089/ars.2007.1720
  3. View record in Web of Science®
  4. WOS: 000249521600013

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel