Skip NavigationSkip to Content
Return Return to Search Results

Defensin participation in innate and adaptive immunity

  1. Author:
    Yang, D.
    Liu, Z. H.
    Tewary, P.
    Chen, Q.
    De la Rosa, G.
    Oppenheim, J. J.

  2. Author Address

    NCI, Basic Res Program, SAIC Frederick Inc, Canc & Inflammat Program,Ctr Canc Res,Lab Mol Imm, Frederick, MD 21702 USA.;Yang, D, NCI, Basic Res Program, SAIC Frederick Inc, Canc & Inflammat Program,Ctr Canc Res,Lab Mol Imm, 1050 Boyles St, Frederick, MD 21702 USA.;dyang@nciterf.gov
    1. Year: 2007
  2. Journal: Current Pharmaceutical Design
    1. 13
    2. 30
    3. Pages: 3131-3139
  4. Type of Article: Review
  5. ISSN: 1381-6128
  1. Abstract:

    Defensins are endogenous, small, cysteine-rich antimicrobial peptides that are produced by leukocytes and epithelial cells. Substantial evidence accumulated in recent years indicates that mammalian defensins are multifunctional and, by interacting with host cell receptor(s), participate in both the innate and adaptive antimicrobial immunity of the host, A better understanding of the function of defensins in immunity has implications for the development of potential clinical therapeutics for the treatment of infection or cancer. Here we will briefly outline the classification, genes, expression, and structure of mammalian defensins and focus on their roles in innate and adaptive immune response of the host.

    See More

  1. Keywords:

External Sources

  1. View record in Web of Science®
  2. WOS: 000250570600008

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel