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Regulatory polymorphisms in the interleukin-18 promoter are associated with hepatitis C virus clearance

  1. Author:
    An, P.
    Thio, C. L.
    Kirk, G. D.
    Donfield, S.
    Goedert, J. J.
    Winkler, C. A.

  2. Author Address

    An, Ping, Winkler, Cheryl A.] Sci Applicat Int Corp, Lab Genom Divers, Frederick, MD USA. [Thio, Chloe L.] Johns Hopkins Med Inst, Dept Med, Baltimore, MD 21205 USA. [Kirk, Gregory D.] Johns Hopkins Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA. [Goedert, James J.] NCI, Viral Epidemiol Branch, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Donfield, Sharyne] Rho Inc, Chapel Hill, NC USA.
    1. Year: 2008
  2. Journal: Journal of Infectious Diseases
    1. 198
    2. 8
    3. Pages: 1159-1165
  4. Type of Article: Proceedings Paper
  1. Abstract:

    The immune response is critical in determining the outcome of hepatitis C virus (HCV) infection. Interleukin (IL)-18 is a pivotal mediator of the Th1/Th2-driven immune response. Two IL-18 promoter polymorphisms (-607C/A and -137G/C) and their haplotypes were known to affect IL-18 expression. We examined the role played by these polymorphisms in determining HCV clearance or persistence. Genotyping was performed among African American injection drug users with HCV clearance (n = 91) or HCV persistence ( n = 182) and among European Americans with hemophilia who were mainly infected through plasma transfusion. Among injection drug users, IL18 -607A (odds ratio [OR], 3.68 [95% confidence interval{CI}, 1.85-7.34]) and IL18 -137C ( OR, 2.33 [95% CI, 1.24-4.36]) were significantly associated with HCV clearance. A haplotype carrying -607A and -137C (OR, 4.53 [95% CI, 1.77-11.6]) was also strongly associated with viral clearance. No association was found among those with hemophilia. These results suggest that IL-18 promoter polymorphism may affect the outcome of HCV infection in certain groups.

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External Sources

  1. PMID: 18781864

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