Skip NavigationSkip to Content
Return Return to Search Results

Aryl Bis(diazeniumdiolates): Potent Inducers of S-Glutathionylation of Cellular Proteins and Their in Vitro Antiproliferative Activities

  1. Author:
    Andrei, D.
    Maciag, A. E.
    Chakrapani, H.
    Citro, M. L.
    Keefer, L. K.
    Saavedra, J. E.

  2. Author Address

    Maciag, Anna E.; Citro, Michael L.; Saavedra, Joseph E.] Natl Canc Inst Frederick, SAIC Frederick, Basic Res Program, Ft Detrick, MD 21702 USA. [Andrei, Daniela, Chakrapani, Harinath, Keefer, Larry K.] Natl Canc Inst Frederick, Chem Sect, Comparat Carcinogenesis Lab, Ft Detrick, MD 21702 USA.
    1. Year: 2008
  2. Journal: Journal of Medicinal Chemistry
    1. 51
    2. 24
    3. Pages: 7944-7952
  4. Type of Article: Article
  1. Abstract:

    A number of bis(diazeniumdiolates) that we designed to release up to 4 mol of nitric oxide (NO) and that are structural analogues of the NO prodrug and anticancer lead compound O-2-{2,4-dinitro-5-[4-(N-methylamino)benzoyloxy]phenyl} 1-(N,N-dimethylamino)diazen-1-ium-1,2-diolate (PABA/NO) were synthesized and studied. A majority of these compounds yielded higher levels of NO, were better inhibitors of proliferation of a number of cancer cell lines, and more rapidly induced substantially increased levels of S-glutathionylation of cellular proteins in comparison with PABA/NO. In most cases, the antiproliferative activity and extents of S-glutathionylation correlated well with levels of intracellular NO release. We report bis(diazeniumdiolates) to be a class of S-glutathionylating agents with potent antiproliferative and S-glutathionylating activity.

    See More

  1. Keywords:

External Sources

  1. View Full Text
  2. DOI: 10.1021/jm800831y
  3. PMID: 19053760
  4. View record in Web of Science®
  5. WOS: 000261876400031

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel