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Genetic variants in the 8q24 locus and risk of testicular germ cell tumors

  1. Author:
    Cook, M. B.
    Graubard, B. I.
    Quraishi, S. M.
    Yeager, M.
    Chanock, S. J.
    Crenshaw, A.
    Erickson, R. L.
    Rubertone, M. V.
    Thomas, G.
    McGlynn, K. A.

  2. Author Address

    Cook, Michael B.; Graubard, Barry I.; Quraishi, Sabah M.; Yeager, Meredith, Chanock, Stephen J.; Crenshaw, Andrew, Thomas, Gilles, McGlynn, Katherine A.] NCI, NIH, DHHS, Div Canc Epidemiol & Genet, Bethesda, MD 20892 USA. [Yeager, Meredith, Crenshaw, Andrew] NCI, SAIC Frederick Inc, Adv Technol Program, Core Genotyping Facil, Frederick, MD 21702 USA. [Erickson, Ralph L.] Walter Reed Army Inst Res, Global Emerging Infect Syst, Silver Spring, MD 20910 USA. [Rubertone, Mark V.] USA, Ctr Hlth Promot & Prevent Med, Washington, DC 20307 USA.
    1. Year: 2008
  2. Journal: Human Genetics
    1. 123
    2. 4
    3. Pages: 409-418
  4. Type of Article: Article
  1. Abstract:

    Much evidence supports the premise that population genetic variation contributes significantly to the risk of testicular germ-cell tumor (TGCT). However, investigations of the association between genomic markers and TGCT susceptibility are scarce. Single nucleotide polymorphisms (SNPs) at the locus 8q24 have recently been found to be associated with prostate, colorectal and breast cancer. The US Servicemen's testicular tumor environmental and endocrine determinants (STEED) study was used to investigate the association of 15 specific 8q24 SNPs with TGCT and its two main histologic groups of seminoma and nonseminoma. Conditional and unconditional logistic regression models, adjusted for the matching variables of year of birth, race/ethnicity and serum date, were utilized to produce odds ratios (OR) and 95% confidence intervals (95%CI). The analysis included 680 controls and 568 TGCT cases. In the TGCT analysis, no SNP was associated with risk in both heterozygotes and variant homozygotes. When stratified by histology the seminoma analysis also showed no association with the 8q24 SNPs. Conversely, the analysis of nonseminomas had three tentative associations (rs6470494, ORgenotype AG = 1.15, 95%CI: 0.86-1.54, ORgenotype GG = 1.68, 95%CI: 1.04-2.73, p for trend = 0.04) (rs13254738, ORgenotype GT = 1.04, 95%CI: 0.77-1.40, ORgenotype TT = 1.62, 95%CI: 1.06-2.49, p for trend = 0.07) (rs10505476, ORgenotype CT = 0.67, 95%CI: 0.50, 0.91, ORgenotype TT = 0.81, 95%CI: 0.47-1.39, p for trend = 0.04). There was no linkage disequilibrium between any of the 8q24 SNPs analyzed in this population. In conclusion, this study has found little evidence for an association between the reported 8q24 SNPs and TGCTs, although the findings for nonseminoma may be worth further investigation.

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External Sources

  1. PMID: 18373104

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