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CD4 T cell survival after intermittent interleukin-2 therapy is predictive of an increase in the CD4 T cell count of HIV-infected patients

  1. Author:
    Read, S. W.
    Lempicki, R. A.
    Di Mascio, M.
    Srinivasula, S.
    Burke, R.
    Sachau, W.
    Bosche, M.
    Adelsberger, J. W.
    Sereti, I.
    Davey, R. T.
    Tavel, J. A.
    Huang, C. Y.
    Issaq, H. J.
    Fox, S. D.
    Lane, H. C.
    Kovacs, J. A.

  2. Author Address

    Read, Sarah W.] NIAID, Div Aids, Bethesda, MD 20892 USA. [Di Mascio, Michele, Huang, Chiung-Yu] NIAID, Biostat Res Branch, Bethesda, MD 20892 USA. [Tavel, Jorge A.] NIAID, Div Clin Res, Bethesda, MD 20892 USA. [Burke, Rosanne, Sachau, William, Sereti, Irini, Davey, Richard T., Jr.; Lane, H. Clifford] NIAID, Immunoregulat Lab, Bethesda, MD 20892 USA. [Kovacs, Joseph A.] NIH, Ctr Clin, Dept Crit Care Med, Bethesda, MD 20892 USA. [Srinivasula, Sharat] NCI, Biostat Res Branch, Frederick, MD 21701 USA. [Issaq, Haleem J.; Fox, Stephen D.] NCI, Adv Technol Program, Lab Prote & Analyt Technol, Frederick, MD 21701 USA. [Lempicki, Richard A.; Bosche, Marjorie, Adelsberger, Joseph W.] NCI, Sci Applicat Int Corp, Frederick, MD 21701 USA.
    1. Year: 2008
  2. Journal: Journal of Infectious Diseases
    1. 198
    2. 6
    3. Pages: 843-850
  4. Type of Article: Proceedings Paper
  1. Abstract:

    Administration of interleukin (IL)-2 to human immunodeficiency virus (HIV) -infected patients leads to significant increases in CD4 T cell counts. We previously have shown that IL-2 induces increased proliferation and survival of CD4 T cells. Deuterium labeling studies were undertaken to study the relationship between IL-2 induced increases in the CD4 Tcell count and the effects of IL-2 on cell proliferation and survival. A strong inverse correlation was noted between the rate of decay of the label in CD4 cells and increases in CD4 cell counts (R= -0.67, P<. 001). This correlation was not seen with the level of proliferating cells. Although the CD4 cell count at baseline and the number of CD4 cells expressing CD25 were also predictive of increases in the CD4 cell count, the rate of decay remained the most statistically significant predictor in multivariate regression models. Thus, an increase in the survival ofCD4T cells appears to be the critical mechanism leading to sustained increases in the CD4 cell counts of HIV-infected patients receiving intermittent IL-2 therapy.

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External Sources

  1. PMID: 18684102

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