Skip NavigationSkip to Content
Return Return to Search Results

Application of a trifunctional reactive linker for the construction of antibody-drug hybrid conjugates

  1. Author:
    Thomas, J. D.
    Hofer, T.
    Rader, C.
    Burke, T. R.

  2. Author Address

    Thomas, Joshua D.; Burke, Terrence R., Jr.] NCI, NIH, Med Chem Lab, CCR, Frederick, MD 21702 USA. [Hofer, Thomas, Rader, Christoph] NCI, NIH, Expt Transplantat & Immunol Branch, CCR, Bethesda, MD 20892 USA.
    1. Year: 2008
  2. Journal: Bioorganic & Medicinal Chemistry Letters
    1. 18
    2. 21
    3. Pages: 5785-5788
  4. Type of Article: Article
  1. Abstract:

    A flexible, trifunctional poly(ethylene glycol)-succinamide-Lysine-Lysine-maleimide (PEG-SU-Lys-Lysmal) linker was employed to simultaneously allow biotin tagging and cell-surface targeting through an integrin alpha(4)beta(1)-binding peptidomimetic that was regiospecifically conjugated to an IgG1-derived Fc fragment with an engineered C-terminal selenocysteine residue. The resulting antibody derivative mediates Fc receptor binding by virtue of the Fc protein and selectively targets cancer cells expressing human integrin alpha(4)beta(1). The PEG-SU-Lys-Lys-mal linker may have general utility as an organic tether for the construction of antibody-drug conjugates. (C) 2008 Elsevier Ltd. All rights reserved.

    See More

  1. Keywords:

External Sources

  1. No sources found.

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel