Skip NavigationSkip to Content
Return Return to Search Results

Evaluation of IL10, IL19 and IL20 gene polymorphisms and chronic hepatitis B infection outcome

  1. Author:
    Truelove, A. L.
    Oleksyk, T. K.
    Shrestha, S.
    Thio, C. L.
    Goedert, J. J.
    Donfield, S. M.
    Kirk, G. D.
    Thomas, D. L.
    O'Brien, S. J.
    Smith, M. W.

  2. Author Address

    Truelove, Ann L.; Oleksyk, Taras K.; Shrestha, Sadeep, O'Brien, Stephen J.; Smith, Michael W.] NCI, Lab Genom Divers, Frederick, MD 21702 USA. [Truelove, Ann L.; Oleksyk, Taras K.; Shrestha, Sadeep, Smith, Michael W.] NCI, SAIC Frederick Inc, Basic Res Program, Frederick, MD 21702 USA. [Thio, Chloe L.; Thomas, David L.] Johns Hopkins Univ, Dept Med, Baltimore, MD USA. [Goedert, James J.] NCI, Div Canc Epidemiol & Genet, Infect & Immunoepidemiol Branch, Rockville, MD USA. [Donfield, Sharyne M.] Rho Inc, Chapel Hill, NC USA. [Kirk, Gregory D.; Thomas, David L.] Johns Hopkins Univ, Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
    1. Year: 2008
  2. Journal: International Journal of Immunogenetics
    1. 35
    2. 3
    3. Pages: 255-264
  4. Type of Article: Article
  1. Abstract:

    Hepatitis B virus (HBV) infection remains a serious global health problem despite the availability of a highly effective vaccine. Approximately 5% of HBV-infected adults develop chronic hepatitis B, which may result in liver cirrhosis or hepatocellular carcinoma. Variants of interleukin-10 (IL10) have been previously associated with chronic hepatitis B infection and progression to hepatocellular carcinoma. Single nucleotide polymorphisms (SNP, n = 42) from the IL10, IL19 and IL20 gene regions were examined for an association with HBV infection outcome, either chronic or recovered, in a nested case-control study of African Americans and European Americans. Among African Americans, three nominally statistically significant SNP associations in IL10, two in IL20, and one haplotype association were observed with different HBV infection outcomes (P = 0.005-0.04). A SNP (rs1518108) in IL20 deviated significantly from Hardy-Weinberg equilibrium in African Americans, with a large excess of heterozygotes in chronic HBV-infected cases (P = 0.0006), which suggests a strong genetic effect. Among European Americans, a nominally statistically significant SNP association in IL20 and an IL20 haplotype were associated with HBV recovery (P = 0.01-0.04). These results suggest that IL10 and IL20 gene variants influence HBV infection outcome and encourage the pursuit of further studies of these cytokines in HBV pathogenesis.

    See More

  1. Keywords:

External Sources

  1. PMID: 18479293

Library Notes

  1. No notes added.
NCI at Frederick

You are leaving a government website.

This external link provides additional information that is consistent with the intended purpose of this site. The government cannot attest to the accuracy of a non-federal site.

Linking to a non-federal site does not constitute an endorsement by this institution or any of its employees of the sponsors or the information and products presented on the site. You will be subject to the destination site's privacy policy when you follow the link.

ContinueCancel